Editor in Chief

Dr Paolo Melillo received his Ph.D. degree in Health Management in 2012 from the University of Naples “Federico II”. He is Assistant Professor at the Multidisciplinary Department of Medical, Surgical and Dental Sciences of the Second University of Naples, Italy. He has authored or coauthored about 50 scientific publications. His research activity is now focused on advanced methods in ophthalmology…

Name : Paolo Melillo
University : Second University of Naples

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Recent Articles

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    Clover Leaf Vision: Persistent Placoid Maculopathy

    A 51-year-old woman, presented with bilateral decreased central vision over a 3- week period. She states that there is a smudge in her central vision, “the shape of a cloverleaf” (Figure 1). She has an unremarkable past medical history with the exception of a viral illness one-month prior.

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    Persistent Fetal Vasculature with Atypical Presentation

    Persistent fetal vasculature is an uncommon condition, presenting clinically as Leukocoria (white pupillary reflex), micro-ophthalmia, and cataract. The authors report a case of an infant with atypical normal corneal diameter and long axial length sizes.

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    Chronic Post-operative Endophthalmitis due to Propionibacterium Acnes

    An 82-year-old female presented with a four month history of left eye glare and visual acuity disturbance. History included dyslipidemia and hypertension. The patient’s ocular history included left eye open angle glaucoma, which was diagnosed about three years earlier; she had undergone bilateral cataract removal ten years earlier.

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PubMed Indexed Articles

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    Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol

    The fate of mouse uterine epithelial progenitor cells is determined between postnatal days 5 to 7. Around this critical time window, exposure to an endocrine disruptor, diethylstilbestrol (DES), can profoundly alter uterine cytodifferentiation. We have shown previously that a homeo domain transcription factor MSX-2 plays an important role in DES-responsiveness…

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    Brain Uptake of Neurotherapeutics after Intranasal Delivery in Mice

    There is a growing global prevalence of neurodegenerative diseases such as Alzheimer’s disease and dementia. Current treatment for neurodegenerative diseases is limited due to the blood brain barrier’s ability to restrict the entry of therapeutics to the brain. In that context, direct delivery of drugs from nose to brain has gained emerging interest…

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    Current Studies of Immunotherapy on Glioblastoma

    Glioblastoma is a form of brain tumor with a very high morbidity and mortality. Despite decades of research, the best treatments currently in clinical practice only extend survival by a number of months. A promising alternative to conventional treatment for glioblastomas is immunotherapy. Although proposed over a century ago, the field of cancer immunotherapy…

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