Elyns Journal of Cancer Research

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Neelesh Sharma

Designation : Assistant Professor
University/Organisation : Case Western Reserve University
Qualification : M.D, Ph.D
Biography :  

Dr. Neelesh Sharma currently working as assistant professor of thoracic oncology at University Hospitals, Case Western Reserve University, Cleveland, Ohio.  He is a medical oncologist with interest in translating bench side research to early phase clinical trials. His research focus is to find novel treatment options for EGFR TKI resistant non small cell lung cancer and treatment of KRAS mutant lung cancer. He have shown that combination of EGFR inhibitors with a new class of drugs (curaxins) can increase the efficacy of EGFR TKI in otherwise resistant non small cell lung cancer cell lines. Curaxins can simultaneously suppress NF-kappaB and activate p53 by targeting FACT. Based on this work he is conducting a Phase I clinical trial of erlotinib and quinacrine in advanced lung cancer patients.