Elyns Journal of Microbes

Some New Neonatal Human Infections: New Problems in Clinical Microbiology

Download PDF

Published Date: September 02, 2015

Some New Neonatal Human Infections:  New Problems in Clinical Microbiology

Viroj Wiwanitkit

Professor, Senior Expert, Surin Rajabhat University, Surin, Thailand
Visiting professor, Hainan Medical University, China
Visiting professor, Faculty of Medicine, University of Nis, Serbia
Adjunct professor, Joseph Ayobabalola University, Nigeria
Honorary professor, Dr DY Patil Medical University, India

Corresponding author: Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok Thailand 10160, Email: wviroj@yahoo.com

Citation: Viroj Wiwanitkit (2015) Some New Neonatal Human Infections: New Problems in Clinical Microbiology. Ely J Micro 1(1): 101e. http://dx.doi.org/10.19104/amb.2015.101e


Editorial Note


Many new emerging viral diseases have been discovered for few years. Those new diseases become the new problems in clinical microbiology. In medicine, the new viral infection is a serious problem and the disease caused by the new virus is usually difficult to manage. Hence, those new infections become the new focuses in clinical microbiology. There are many new infections that should be mentioned. Those new emerging viruses within the past 3 years will be further discussed. First, human parechovirus infection is a new viral disease. The human parechovirus infection can result in neonatal neurological infection [1]. The affected neonate usually has meningitis [2].   Luo et al. also noted the virus can also induce sepsis [3]. However, the disease usually present as febrile illness that brings difficulty in diagnosis. To diagnose this disease, the molecular diagnosis is required [4].   For serious case, fatal leukoencephalopathy can be seen [5].  Second, Tusavirus 1 is a new parvovirus that causes infection in neonate. This infection was firstly seen in Tunisia and the virus is believed to be the cause of diarrhea [6]. In fact, another new virus has just been detected in Bhutan [7]. The virus is Bufavirus 3 and it cause diarrhea in children. Finally, there is another report on new recombinant echovirus 25 strain with Coxsackievirus B3 in a neonatal patient with hand, foot, and mouth disease complicated by encephalitis [8]. Of interest, those new viral infections in neonate warrant for further researches for finding proper diagnosis, treatment and prevention.

Top ↑



  1. Esposito S, Rahamat-Langendoen J, Ascolese B, Senatore L, Castellazzi L, Niesters HG. Pediatric parechovirus infections. J Clin Virol. 2014;60(2):84-9. doi: 10.1016/j.jcv.2014.03.003.
  2. Seo JH, Yeom JS, Youn HS, Han TH, Chung JY. Prevalence of human parechovirus and enterovirus in cerebrospinal fluid samples in children in Jinju, Korea. Korean J Pediatr. 2015;58(3):102-7. doi: 10.3345/kjp.2015.58.3.102.
  3. Luo L, Zhu R, Zhao L, Deng J, Wang F, Sun Y,et al. Human parechovirus associated sepsis and central nervous system infections in hospitalized children. Zhonghua Er Ke Za Zhi. 2014;52(6):444-8.
  4. Piralla A, Mariani B, Stronati M, Marone P, Baldanti F. Human enterovirus and parechovirus infections in newborns with sepsis-like illness and neurological disorders. Early Hum Dev. 2014;90 Suppl 1:S75-7. doi: 10.1016/S0378-3782(14)70023-4.
  5. Bissel SJ, Auer RN, Chiang CH, Kofler J, Murdoch GH, Nix WA, et al. Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy. J Neuropathol Exp Neurol. 2015;74(8):767-77. doi: 10.1097/NEN.0000000000000215.
  6. Phan TG, Sdiri-Loulizi K, Aouni M, Ambert-Balay K, Pothier P, Deng X, et al. New parvovirus in child with unexplained diarrhea, Tunisia. Emerg Infect Dis. 2014;20(11):1911-3. doi: 10.3201/eid2011.140428.
  7. Yahiro T, Wangchuk S, Tshering K, Bandhari P, Zangmo S, Dorji T, et al. Novel human bufavirus genotype 3 in children with severe diarrhea, Bhutan. Emerg Infect Dis. 2014;20(6):1037-9. doi: 10.3201/eid2006.131430.
  8. Li H, Meng Y, Pang L, Liang J, Lu H, Wang Q, et al.  Complete genome sequence of a new recombinant echovirus 25 strain isolated from a neonatal patient with hand, foot, and mouth disease complicated by encephalitis in Beijing, China. Virus Genes. 2015;50(3):505-8. doi: 10.1007/s11262-015-1186-9.

Top ↑

Copyright: © 2015 Viroj Wiwanitkit. This is an open access article distributed under the Creative Commons Attribution License, which ermits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.