Journal of Stem Cell and Transplantation Biology

Archive

  • Research article - Lifesciences Published: May 12, 2015

    Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol

    The fate of mouse uterine epithelial progenitor cells is determined between postnatal days 5 to 7. Around this critical time window, exposure to an endocrine disruptor, diethylstilbestrol (DES), can profoundly alter uterine cytodifferentiation. We have shown previously that a homeo domain transcription factor MSX-2 plays an important role in DES-responsiveness…

    -Yan Yin, Congxing Lin, Ivy Zhang, Alexander V Fisher, Maulik Dhandha and Liang Ma

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  • Review article - Lifesciences Published: Jan 24, 2015

    Direct Reprogramming Facilitated by Small Molecules

    The ability to reprogram cellular fate provide great hope for regenerative medicine and offer excellent cellular resources for disease modeling and drug discovery. Direct reprogramming, also called lineage reprogramming or transdifferentiation, is the process of changing one cell type to another without going through an intermediate pluripotent step. Direct reprogramming…

    -Conner Lewis, Blake Brewster, E Tian and Yanhong Shi

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  • Research article - Lifesciences Published: May 22, 2015

    Derivation of Engrafting Skeletal Muscle Precursors from Human Embryonic Stem Cells Using Serum-Free Methods

    Degenerative muscle diseases affect muscle tissue integrity and function. Human embryonic stem cells (hESC) are an attractive source of cells to use in regenerative therapies due to their unlimited capacity to divide and ability to specialize into a wide variety of cell types. A practical way to derive therapeutic myogenic…

    -Karlijn J. Wilschut, Wenhui Gong, Peter E. Oishi and Harold S. Bernstein

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  • Review article - Lifesciences Published: Apr 20, 2015

    Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering

    Myocardial infarction (MI) is the leading cause of death worldwide. Recent advances in stem cell research hold great potential for heart tissue regeneration through stem cell-based therapy. While multiple cell types have been transplanted into MI heart in preclinical studies or clinical trials, reduction of scar tissue and restoration of…

    -Shuo Tian, Qihai Liu, Leonid Gnatovskiy, Peter X. Ma, Zhong Wang

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  • Review article - Lifesciences Published: Mar 24, 2015

    Neural Stem Cells and Induced Neurons for Nerve Injury Repair

    Cell transplantation can relieve the symptoms of reverse neurodegenerative diseases and repair nerve injuries. Fibroblast growth factor 1 promotes neuronal survival and stimulates axonal growth. A combination of fibroblast growth factor 1 and cell-based therapy is promising for nerve repair. Developers of future cell-based treatment should consider several key concerns:…

    -Yi Chao Hsu, Su Liang Chen, Tai Yu Hsu, and Ing Ming Chiu

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