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  • Research article - Medical Published: Oct 18, 2017

    Single Center Retrospective Comparison of the TargetedCombination Therapies in Melanoma Patients

    Melanoma has a high mortality rate and the fastest growing global incidence rate of all malignancies, increasing in an exponential mannerPublished Date: October 18, 2017. Moreover there was no effective treatment for melanoma 2011. That is why melanoma research has been a hotpoint nowadays. We know now that patients with…

    -Eszter Gorka, András Gézsi, Kata Czirbesz, and Gabriella Liszkay

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  • Research article - Medical Published: Dec 07, 2017

    Role of Tau Acetylation in Alzheimer’s Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment

    Tau hyperphosphorylation and progression have long dominated the underlying dogma behind disease progression in Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE). Multiple treatment strategies have been employed to prevent tau hyperphosphorylation or tau deposition as well as preventing amyloid deposition in AD. Unfortunately, these flawed hypotheses have failed to…

    -Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles Rosen,

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  • Case report - Medical Published: Oct 13, 2017

    A Heart Touched by “The Devil’s Tongue”: Near Fatal Pulmonary Embolism

    A 73–year old man with a history of hypertension, attended the emergency room presenting syncope, dyspnea, and chest tightness with inspiratory efforts. In emergency room the patient's mental status was obtunded, his heart rate was 84 beats per minute, respiratory rate 28 breaths per minute; oxygen saturation was 88% with…

    -Aaron B. Ortiz*, David C. Alonso, and Sergio S. Noguero

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  • Review article - Medical Published: Oct 03, 2017

    Are Changes in the Wnt/?-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?

    Drug addiction has been defined as a chronic relapsing brain disease, characterized by compulsive drug seeking and use, despite harmful consequences. This phenomenon has been extensively studied and the use of animal models has contributed to elucidate neurobiological bases of the different stages in the addiction process. For the past…

    -Santiago Cuesta and Alejandra M. Pacchioni

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  • Research article - Medical Published: Oct 05, 2017

    Development of the Short-Term Life Review Performed by Nurses as Spiritual and Psychological Care for Terminally Ill Cancer Patients

    Terminally ill cancer patients experience various mental and psychological problems, including depression, which has a pooled mean prevalence in cancer patients of 8–24%, and psycho-existential suffering. The elderly population is increasing worldwide and the number of elderly people is expected to increase in Japan. Many people will confront psycho-existential suffering…

    -Michiyo Ando, Tatsuya Morita, Keio Tamura, Kaori Fukuta, Kengo Imai, Atsuko Yoshida, and Yosuke Uchi

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